by Dr Gene | Jul 26, 2025 | Midlife Wellness, Women Health
“I Don’t Feel Like Myself Anymore.”
It’s subtle at first.
You’re not falling apart.
You’re just… not fully here either.
You’re doing the same things, working, helping, holding it all together, but it’s like you’ve left part of yourself behind somewhere.
This is what many women describe as a midlife crisis.
But what if it’s not a crisis?
What if it’s a call to recalibrate?
Midlife Isn’t a Decline, It’s a Reprogramming
Between ages 35–55, your body, brain, hormones, and nervous system go through enormous transformation.
It’s not just aging.
It’s rewiring.
You are not broken.
You’re being invited to change, how you pace, how you nourish, how you relate, how you live.
Midlife isn’t when you lose yourself.
It’s when your body asks you to finally meet who you’ve been all along.
5 Real Reasons Midlife Feels Like a Crisis
1. Your Biology Is Changing, but No One Tells You That
Perimenopause, estrogen shifts, cortisol spikes, these affect mood, motivation, energy, digestion, and even memory.
But instead of support, women are told:
“You’re just stressed.”
Or worse: “It’s all in your head.”
What helps:
- Warm food, early sleep, daily movement
- Less pressure. More rhythm.
- Understanding that your biology is adapting, not failing.
2. You’ve Outgrown the Role You’ve Been Playing
Many women wake up in midlife and feel like they’re acting out a version of themselves that no longer fits.
Not because something’s wrong, but because you’ve evolved.
What helps:
- Honoring the discomfort as wisdom
- Letting parts of you die (the over-doer, the fixer, the performer)
- Making space to meet who’s emerging
3. Your Nervous System Is Tired of Pretending Everything’s Fine
By midlife, your body has likely carried years of responsibility, grief, over-efforting, and emotional suppression.
And now? It wants out.
That’s why your body “sabotages” you with fatigue, skin issues, mood swings, and more.
These aren’t symptoms.
They’re requests.
What helps:
- Nervous system recovery: slow mornings, deep breaths, daily joy
- Emotional release: writing, movement, safe conversations
- Learning to stop performing calm, and actually feel it
4. You’ve Been Surviving, Not Living
Your days are full, yet empty.
You’re functioning, but not flourishing.
This isn’t failure.
It’s a wake-up call.
To joy. To purpose. To self-respect.
What helps:
- Reclaim joy as a nutrient
- Say no faster, more often, and without guilt
- Schedule restoration like it matters (because it does)
5. You’ve Never Been Taught to Trust Your Own Wisdom
Midlife is often when intuition screams the loudest, but you’ve been trained to second-guess yourself.
This is the time to unlearn the doubt, not push it deeper.
What helps:
- Listening to your gut before your inbox
- Noticing what your body reacts to, foods, people, pace
- Creating space between input and response
So What Is Midlife Really Asking You To Do?
Here’s what I’ve learned from science, from women I work with, and from my own experience:
Midlife doesn’t ask you to be stronger. It asks you to become more honest.
Honest about:
- What’s working and what’s not
- What you’ve been tolerating
- What kind of life your body can actually thrive in
And when you listen to those truths, without fear, healing begins. Energy returns. Joy reappears.
Midlife Isn’t a Crisis. It’s a Return.
To your voice.
To your rhythm.
To your self-respect.
To your softness.
To your power.
Let go of the language that says something is wrong with you.
And replace it with one that honors what’s waking up in you.
Because the woman you’re becoming?
She’s not behind.
She’s on time.
Ready to come back to yourself?
Follow me on Instagram @eugene_antenucci for daily insights on midlife health, energy, clarity, and self-trust.
Explore Living Longer, Living Better or The Forever Human for guidance that honors your evolution.
by Dr Gene | Jul 25, 2025 | Mental Health
“I Don’t Have Time to Burn Out.”
If you’ve ever said that, read this slowly.
Because the pace you’re living at may be the very thing quietly burning you out.
Not because you’re weak, unfit, or doing something wrong but because your biology is not built for constant speed.
And no one’s talking about it.
Your Pace Is a Signal to Your Body
Your body listens to rhythm more than rules.
It doesn’t care how many steps you hit or how many greens you ate today, if you’re rushing from task to task, fight to freeze, screen to screen…it activates survival mode.
Here’s what that mode looks like:
- Cortisol spikes (your stress hormone)
- Hormonal imbalance
- Gut shutdown
- Shallow breath
- Tight jaw, brain fog, fatigue
- Skin issues, bloat, reactive emotions
All of this happens quietly. Daily.
Until it shows up as a symptom you can’t ignore.
5 Ways a Fast-Paced Life Wears Down a Woman’s Health
1. Your Nervous System Thinks You’re in Danger
When your day has no built-in pause, no moment of true stillness, your body never downshifts.
That means digestion, sleep quality, hormone regulation, and cellular repair all suffer.
What helps:
- One 5-minute “nothing” break midday (no phone, no input)
- Lying down with one hand on your heart, one on belly, eyes closed
- Walking without a goal, just for rhythm
2. Your Hormones Can’t Keep Up
Fast living overstimulates cortisol and depletes progesterone, which is critical for emotional balance, sleep, and fertility.
It also disrupts insulin and thyroid function.
What helps:
- Evening meals before 7 PM
- Lower caffeine after 12 PM
- More warmth: in meals, lighting, and voice
3. You Don’t Recover, You Pause Just Long Enough to Keep Going
There’s a difference between real rest and functional collapse.
Many women take 10-minute breaks that feel more like crashes than resets.
What helps:
- Scheduling breaks like meetings
- No “multitasking rest” (e.g. scrolling in bed doesn’t count)
- Evening rituals that feel slow, tea, music, oil massage, breathwork
4. You’re Breathing Like You’re Running, Even When You’re Sitting Still
Shallow breathing triggers your stress response.
Over time, it leads to low oxygen, poor sleep, and tension in the shoulders, face, and pelvic floor.
What helps:
- Mouth closed, nasal breathing only
- 5 breaths in/out before emails or calls
- Gentle sighs. They count.
5. You’ve Lost the Joyful Rhythms That Kept You Human
Where’s your morning stretch?
Your long exhale before bed?
Your phone-free walk around the block?
When pace replaces rhythm, your body doesn’t just age faster, it forgets how to feel good.
What helps:
- Replace one rush with one ritual
- Reclaim joy from noise
- Let silence in again
How to Slow Down—Without Quitting Everything
Let’s be honest.
Most women can’t drop everything and move to a farmhouse.
You still have deadlines. Kids. Clients. Expectations.
But here’s the truth:
You don’t need to leave your life to change your pace.
You just need to create micro-moments of recovery inside it.
Try this:
- 3 minutes of sun on your skin in the morning
- Warm meals eaten slowly, without devices
- A “no input” window before bed
- One quiet pause in your day (even in the car)
- Reframing urgency: “Is this actually an emergency?”
Your Body Doesn’t Want to Work Against You.
It Wants to Work With You.
The fatigue you feel? It’s not failure.
It’s data.
It’s your biology telling you:
“Please stop sprinting. We were never meant to live like this.”
And the most powerful health shift you can make may not be a supplement, a workout, or a detox, but the decision to slow down long enough to hear yourself again.
Final Thought: Your Pace Is Part of Your Healing
The women who feel strong in their 40s and 50s aren’t pushing harder. They’ve simply stopped confusing pressure with progress. And they’ve learned to let rest become a strategy, not a last resort.
Health isn’t a program.
It’s a rhythm.
And rhythm requires space.
Ready to reclaim your rhythm?
Follow me on Instagram @eugene_antenucci for daily tools to slow down, reset your nervous system, and live with intention. Explore Living Longer, Living Better and The Forever Human for more grounded ways to build true vitality.
by Dr Gene | Jul 24, 2025 | Stress Management
“I Feel Older Than I Am.”
If you’ve ever looked in the mirror and thought, “I just look… tired,” you’re not being vain.
You’re being honest.
And more often than not, the culprit isn’t time.
It’s stress.
From thinning skin and brittle nails to fatigue, bloating, and brain fog, chronic stress doesn’t just change how we feel.
It changes how we age.
But here’s the good news:
Aging from stress is reversible.
When you remove the pressure, the body remembers how to repair.
Let’s talk about how.
The Science: What Stress Actually Does to Your Body
Stress isn’t just a feeling. It’s a biochemical event, one that triggers a hormonal chain reaction that accelerates aging.
When stress becomes chronic, it:
- Raises cortisol, your stress hormone
- Suppresses collagen production (affecting skin, joints, gut lining)
- Damages the gut microbiome (causing bloating, poor digestion, dull skin)
- Shortens telomeres, the protective ends of your DNA that influence longevity
- Disrupts sleep, detox, and hormone balance, your top anti-aging systems
In other words:
Chronic stress turns your body into a full-time emergency system.
And you can’t repair when you’re running from fire.
How Stress Shows Up as Aging (Even If You Don’t Feel “Stressed”)
Not all stress feels intense. In fact, most aging stress is quiet, constant, and normalized.
Here’s how it might show up:
- You sleep 7 hours… and still feel exhausted.
- Your skin looks dull, thin, or inflamed.
- Your digestion is sluggish, unpredictable, or sensitive.
- Your hair texture or volume is changing.
- Your face looks “puffy but tired.”
- Your motivation is low, even when you’re doing less.
These aren’t cosmetic problems.
They’re physiological warning lights.
5 Subtle Ways Stress Accelerates Aging in Women 35–55
1. Stress Starves Your Skin (and Your Cells)
Cortisol lowers collagen.
It constricts blood flow to the skin, thins it, and delays repair.
You might notice more wrinkles, dullness, or a “flattened” look in the face.
Reverse it with:
- Warm, circulation-boosting meals
- Gentle facial massage (daily lymph movement = glow)
- Collagen-building nutrients: vitamin C, bone broth, slow-cooked stews
2. It Disrupts Your Gut, and Your Glow
Chronic stress weakens digestion, causes bloat, and damages gut lining, reducing nutrient absorption and triggering skin inflammation.
Reverse it with:
- Eating meals seated and slowly
- Bitter foods before eating (arugula, lemon water, ginger)
- Post-meal walks for 10–15 minutes
3. It Shortens Your Telomeres (Your Aging Clock)
Studies show high stress shortens telomeres, protective DNA caps linked to lifespan, repair, and resilience.
Reverse it with:
- 7+ hours of real sleep
- Meaningful connection
- Breathwork or prayer (shown to slow telomere loss)
4. It Robs You of Deep Sleep (Where Repair Happens)
When your body thinks it’s unsafe, it prioritizes survival—not restoration. Even if you sleep, it’s not restorative.
Reverse it with:
- No caffeine after 1 PM
- Darkness by 9:30 PM
- Magnesium-rich foods or baths
- A “no pressure” hour before bed (no emails, no planning)
5. It Speeds Up Emotional Burnout (And Your Face Shows It)
Midlife burnout isn’t always dramatic.
Sometimes, it looks like:
- A tight jaw
- A tired face
- Snapping at small things
- Losing interest in what once brought joy
This state floods the body with inflammatory stress hormones—impacting energy, appearance, immunity, and more.
Reverse it with:
- Restorative movement (like yoga or slow walking, not high-intensity workouts)
- Journaling honestly (emotions are inflammation if unreleased)
- Slowing mornings before the day takes over
What Actually Reverses Stress-Induced Aging?
The key is rhythm, not restriction.
Presence, not punishment.
Here’s what the longest-living, slowest-aging people on Earth have in common:
- They move every day — walking, gardening, carrying
- They eat without guilt — real food, joyful meals
- They rest with purpose — not zoning out, but tuning in
- They belong — community buffers stress more than any supplement
- They breathe deeply, often — rhythm calms the nervous system, which restores repair
You don’t need another “fix.”
You need to reset the pace of your life.
The Real Anti-Aging Secret? Safety.
When your body feels safe, it heals.
Your hormones balance.
Your digestion works.
Your skin glows.
Your thoughts clear.
That’s the truth.
Not anti-aging serums.
Not green powders.
Not chasing the version of you from 10 years ago.
The younger you is not behind you.
She’s waiting inside the version of you who finally feels safe.
Final Thoughts: Aging Can Slow Down, When You Do
Stress ages us. Quietly, consistently, unfairly.
But the body is never static, it listens. It adapts. It wants to repair.
You don’t need to do more.
You need to do what calms your system.
And that starts with honoring your needs, not apologizing for them.
Ready to soften the pace?
Follow me on Instagram @eugene_antenucci for daily insights on health, energy, and slow-aging strategies that nourish your nervous system. Or explore The Forever Human and Living Longer, Living Better, my guides to growing wiser, not just older.
by Dr Gene | Jul 22, 2025 | Women Health
Why Your Energy Isn’t Coming Back. And What to Do About It
If you’re a woman in your 40s or 50s constantly asking, “Why am I always tired?” you’re not imagining it, and you’re not alone.
You’re eating better, trying to sleep more, maybe even exercising… and still, you feel drained. Not just tired, but chronically fatigued, foggy, and somehow disconnected from your own body.
Let’s be clear:
Low energy is not a natural consequence of aging.
It’s a signal. And more importantly, it’s reversible.
The Real Root of Fatigue: It’s Not Just Sleep
Most people think fatigue means:
- Bad sleep
- Low iron
- “Just getting older”
But female fatigue, especially in midlife, is rarely just about sleep. It’s about systemic energy disruption across the nervous system, hormones, metabolism, and emotions.
In short: You don’t need more willpower. You need more alignment.
Top 5 Hidden Reasons for Chronic Fatigue in Women Over 40
1. You’re Eating “Healthy,” But Not Eating for Energy
Many midlife women unknowingly undereat, skip meals, or avoid carbs, all in the name of “eating clean.”
But this spikes cortisol and leads to unstable blood sugar, one of the most common causes of midday fatigue.
Fix it with:
- Warm, balanced meals (protein + fiber + fat + carbs)
- Regular eating times
- No more “just coffee for breakfast”
2. Your Nervous System Is in Survival Mode
Your nervous system regulates energy far more than any supplement.
If your body is constantly bracing, for stress, decisions, overwork, it burns out your energy reserves quietly but consistently.
Fix it with:
- No phone first 30 minutes of the day
- Breathwork before meals
- Walking after dinner (not for weight, for nervous system calm)
3. You’re Taking Supplements but Skipping Recovery
Supplements can support your health, but they cannot replace recovery.
Real energy is restored in deep, predictable rest, not in power naps, doom-scrolling, or 4-minute meditations you forget the next day.
Fix it with:
- A 1-hour “no input” evening window (no screens, no pressure)
- Prioritized bedtime before 11 PM
- Treating sleep as a tool, not a luxury
4. Inflammation Is Draining You. Silently
You may not feel “inflamed.”
But low-grade inflammation is one of the leading causes of low energy in midlife, especially in women.
What causes it?
- Processed food
- Poor gut health
- Emotional suppression
- Overexercise
- Long-term stress
Fix it with:
- More real food
- Less decision fatigue
- Honest emotion, less perfection
5. You’re Resting, but Not Recovering
You can be lying down… and still be on.
If your mind is racing, your breath is shallow, and your heart feels heavy, your body isn’t healing, it’s bracing.
Fix it with:
- Gentle evening routines: warm showers, soft lighting, low stimulation
- Mental boundaries (no planning in bed, no mental downloads after 9 PM)
- Self-kindness: drop the guilt, hold the body like it’s tired—not failing
The Truth: Energy Is Not About Effort. It’s About Alignment
After decades of studying longevity, I can tell you this:
The women who have energy in their 50s and beyond aren’t doing more. They’re doing what matters more often.
They:
- Eat real meals
- Move consistently
- Protect their mornings
- Say no
- Sleep early
- Prioritize community
- Rest with intention
They don’t chase energy.
They protect it.
You’re Not Lazy. You’re Overloaded.
What you’re feeling isn’t a flaw.
It’s the result of living in a world that asks too much from women, and offers too little in return.
So the first step is not a supplement, another cleanse, or another rule.
The first step is permission.
Permission to slow down.
To feel.
To heal.
To live in sync with your own biology.
Final Thought: Energy Can Return, When You Do
If your energy has disappeared, it’s not gone for good.
Your body remembers how to feel good.
It’s just waiting for you to give it space.
Ready to go deeper?
Follow me on Instagram @eugene_antenucci for daily health reminders that support your energy, clarity, and longevity.
Or start your journey with Living Longer, Living Better, my personal guide to building a life that supports the body, not just manages it.
by Dr Gene | Jul 10, 2025 | Age Reversal
Aging is unavoidable, but how we age may be more adaptable than we once assumed. The quest for health, vitality, and longevity is evolving rapidly in the modern era. From embracing cold plunges and fasting to exploring stem cell therapies and gene editing, ongoing discoveries continue to help us support our bodies over time. Among these innovations, one molecule—present in every cell—has gained prominence in conversations about healthy aging: NAD.
Short for nicotinamide adenine dinucleotide, NAD isn’t a futuristic biotech breakthrough; it is already a part of you, playing an essential role in sustaining life and bodily functions. However, as we age, our NAD levels decline, which can trigger a range of age-related issues such as reduced energy, inflammation, slower healing processes, and diminished mental clarity.
Consequently, NAD supplementation has emerged as one of the most promising strategies for enhancing health span and combating age-related diseases. From celebrities to biohackers and even mainstream health enthusiasts, many are now asking: Can boosting NAD levels actually help us age more gracefully?
Let’s delve into the science behind NAD, what happens in your body when you take NAD supplements, and whether this investment is worthwhile.
What Is NAD and Why Is It Important?
NAD is a coenzyme – a type of biological assistant found in every living cell. It is essential for energy production, DNA repair, cellular communication, and regulating our biological clocks. Essentially, NAD converts the food we consume into energy and helps maintain cell integrity.
Unfortunately, NAD levels naturally decline with age. By the time you reach middle age, your NAD levels might be reduced by half compared to what they were in your twenties. This decline is associated with increased oxidative stress, less efficient mitochondrial function, and elevated chronic inflammation—all factors that contribute to the aging process and the onset of diseases such as Alzheimer’s, heart disease, and various metabolic disorders.
Given its crucial role, scientists are exploring methods to restore or maintain optimal NAD levels through lifestyle changes and, increasingly, through supplementation.
How NAD Supplements Work
It’s important to note that “NAD supplements” do not mean you’re ingesting NAD directly. Due to NAD’s instability and the poor absorption it experiences when taken orally, supplements are instead made from precursors—compounds that the body naturally converts into NAD.
The two most extensively studied precursors are:
• Nicotinamide Riboside (NR)
• Nicotinamide Mononucleotide (NMN)
Both of these are forms of vitamin B3 that are deemed safe and well-tolerated. When ingested, your body undergoes a multi-step biochemical process to convert these compounds into NAD.
What Happens When You Supplement With NAD?
Although human research is still in its early phases, the preliminary findings are encouraging.
1. Reduced Inflammation and Improved Metabolic Health
Chronic, low-grade inflammation—often dubbed “inflammaging”—plays a key role in age-related decline. Some studies indicate that NAD precursors may help lower inflammation by bolstering sirtuins, proteins that oversee cellular stress responses, metabolism, and longevity. In various animal and human studies, higher NAD levels correlate with reduced markers of systemic inflammation.
2. Enhanced Cardiovascular Function
Heart disease remains the leading cause of death worldwide. Emerging research suggests that NAD supplementation might protect cardiovascular health by enhancing mitochondrial efficiency in heart cells, reducing oxidative stress, and improving vascular function. For instance, in patients with heart failure, NAD precursors like NMN have shown potential in supporting energy metabolism and lowering inflammatory markers—providing a promising complement to conventional treatments.
3. Support for Muscle Health and Physical Performance
A common aging symptom is the loss of muscle mass and strength. NAD fuels the mitochondria—the powerhouses within muscle cells. In a 2021 randomized controlled trial, older men taking nicotinamide riboside for 12 weeks experienced improvements in grip strength and walking speed, hinting at enhanced physical performance. However, some studies have not shown significant changes in strength, indicating that further research is necessary.
4. Improved Brain Health and Cognitive Function
NAD is also crucial for brain function. Low NAD levels in the brain have been associated with neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease. Preclinical studies have shown that increasing NAD levels can lead to improved learning, memory, and synaptic function. A human study from 2023 noted reductions in insulin resistance and Alzheimer’s-related biomarkers following NAD precursor supplementation, suggesting benefits for cognitive health as well.
Who Should Consider NAD Supplementation?
For most healthy adults, NAD supplements are generally considered safe for short-term use—typically up to 12 weeks—according to experts like Alexandria Hardy, RDN. However, these supplements are not typically suitable for everyone. Children, pregnant women, and individuals with active or previously diagnosed cancers are generally advised against taking NAD supplements. While some animal studies suggest potential benefits, other research raises concerns that NAD-boosting compounds might accelerate the growth of certain cancers by encouraging cell proliferation. This situation highlights the importance of personalized healthcare and the need to consult with a professional before starting any supplementation.
How to Supplement: Forms and Costs
NAD precursors are available in several formats:
• Capsules/Pills: the most common and easily accessible form.
• Lozenges or Sublingual Tablets: offer faster absorption through the mouth’s lining.
• Injections.
• IV Infusion: NAD can also be administered directly into the bloodstream via intravenous therapy, which wellness clinics promote for its rapid impact on energy and recovery.
Among these options, oral supplements—especially NR and NMN—are the most widely used and studied. Prices vary depending on brand, dosage, and delivery method. A typical 30-day supply of NR capsules generally costs between $40 and $90 (often in doses around 250–300 mg per day), while NMN supplements tend to be pricier, ranging from $60 to $150 for a month’s supply. IV NAD therapy, offered by some wellness centers, can cost between $250 and $1,000 per session, with some treatment plans recommending multiple sessions each month. For many, oral NAD precursors offer the best combination of efficacy and affordability for long-term use.
What About Natural Ways to Boost NAD?
Although supplements are the focus here, it’s important to remember that your body can naturally increase NAD with healthy lifestyle habits. Research shows that regular exercise, calorie restriction, intermittent fasting, and quality sleep all contribute to enhanced NAD production. In fact, these natural strategies may work in tandem with supplements to support optimal cellular health.
The Bottom Line: Should You Take NAD?
If your goal is to boost energy, safeguard cognitive function, and lessen the toll of aging on your body, NAD supplementation holds considerable potential. While the science is still unfolding, current research links higher NAD levels with improved health outcomes in older adults. Although it isn’t a miracle cure, NAD appears to be a vital part of the broader picture, including sleep, exercise, nutrition, and a sense of purpose—essential for a long and healthy life.
Nonetheless, it is crucial to approach supplementation with caution and informed guidance. Discuss your options with a healthcare professional, weigh the benefits against the risks, and remember that no supplement can substitute for the fundamental habits that foster genuine vitality.
We are not merely seeking to live longer; we are striving to live better. NAD might just be one of the most exciting tools available to help achieve that goal.
References:
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021;22(2):119-141.
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471.
- Yoshino J, Baur JA, Imai S. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism. 2018;27(3):513-528.
- Trammell SAJ et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016;7:12948.
- Mills KF et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism. 2016;24(6):795–806.
- Elhassan YS et al. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Reports. 2019;28(7):1717–1728.
- Khan NA, Auranen M, Paetau I, et al. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. Cell Metabolism. 2014;19(3):441–448.
- Diguet N, Trammell SA, Tannous C, et al. Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy. Circulation. 2018;137(21):2256-2273.
- Martens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018;9(1):1286.
- Dolopikou CF et al. Nicotinamide riboside supplementation in healthy older adults: Effects on skeletal muscle NAD+ levels and function. Aging Cell. 2021;20(3):e13329.
- Fang EF et al. NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nature Communications. 2019;10(1):5284.
- Hardy A. Personal communication, as cited in EatingWell, 2024.
- Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism. 2018;27(3):529-547.
- Canto C, Menzies KJ, Auwerx J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metabolism. 2015;22(1):31-53.
